Precise. Personalized. Predictive.

Venebio Opioid Advisor Clinical Decision Support

The Opioid Overdose Epidemic

Over the last two decades, prescription opioid-related overdose and deaths from opioid-induced respiratory depression (OIRD) have emerged as a major public health threat in the United States. Overdose deaths involving prescription opioids have quadrupled since 1999 and parallel the striking increase of U.S. sales and consumption of prescription opioids. From 1999 to 2015, more than 183,000 people have died in the U.S. from overdoses related to prescription opioids.

  • Today, nearly half of all U.S. opioid overdose deaths involve a prescription opioid.
  • In 2015, more than 15,000 people died from overdoses involving prescription opioids.
  • Every day, over 1,000 people are treated in emergency departments for misusing prescription opioids.

More about the opioid overdose epidemic.

Venebio Opioid Advisor

In response to the public health threat posed by the opioid overdose epidemic, Venebio Group developed the Venebio Opioid Advisor (VOA) clinical decision support tool to support safer opioid prescribing.

The tool provides an evidence-based, quantitative estimate of a patient’s likelihood of experiencing a life-threatening opioid emergency in the next six months.  It characterizes the patient’s specific risk factor profile and provides individualized, evidence-based, risk-mitigation interventions for the health care professional and patient.

More about Venebio Opioid Advisor.

Our Research

The development of VOA built on our­ previously published predictive models and scoring systems that estimate the level of risk of experiencing an adverse outcome.

VOA has undergone extensive retrospective validation, initially in a case-control study of U.S. military veterans, followed by validation in a more representative population using the IMS PharMetrics Plus™ database of 18+ million prescription opioid users.

Implementing VOA can prevent more than 500 overdoses per 100,000 opioid recipients per year. This translates into preventing over 400 prescription opioid overdose-related emergency department visits, avoiding over 120 hospitalizations, and reducing annual health care costs by $2 million per 100,000 patients receiving opioid therapy.

More about our research.


New Hampshire Board of Medicine Recognizes Venebio Opioid Advisor™ as Approved Prescription Opioid Risk Assessment Tool

RICHMOND, Va. – January 31, 2018 – The New Hampshire Board of Medicine has approved Venebio Opioid Advisor™ (VOA™) as one of the state’s official risk assessment tools for opioid prescribing. New Hampshire state law requires that any opioid risk assessment tool be approved by the New Hampshire Board of Medicine. The […]

Study Revealing Highest Risk Profiles for Prescription Opioid Overdose Published in Pain Medicine

Comprehensive analysis of U.S. prescription opioid users and overdose cases further supports personalized approach to prescription of opioids. RICHMOND, Va. – January 15, 2017 – Individuals suffering from a substance use disorder (SUD) or depression are among those at highest risk for a serious prescription opioid overdose, according to a study […]

Study Validating Venebio Opioid Advisor’s Ability to Identify Patients at Risk of Prescription Opioid Overdose Published in Pain Medicine

Venebio Opioid Advisor is the only validated tool to predict the likelihood of a life-threatening opioid overdose with 90-percent accuracy. RICHMOND, Va. – January 15, 2017 – A study validating the strong performance of Venebio Group’s risk-screening tool for prescription opioid overdose — Venebio Opioid Advisor™ (VOA™) — has been published in the January […]

GAO Report: CMS Needs to Broaden Opioid Efforts to Identify and Address Those at Risk for Serious Harm

The Centers for Medicare and Medicaid Services (CMS) have focused for years on identifying opioid-treated beneficiaries at risk for serious harm such as overdose or addiction. Their approach has concentrated on patients prescribed high daily doses of opioids who also have indicators of opioid misuse or abuse, such as ‘doctor […]

Naloxone: An important tool, but not the solution to the opioid crisis

A recent study conducted at Brigham and Women’s Hospital showed that an opioid overdose patient who receives Naloxone and recovers from the overdose, and is subsequently discharged has a one-in-ten chance of dying within a year. The authors acknowledge that Naloxone is an important tool in fighting the opioid crisis, but does not provide […]

Are Prescription Drug Monitoring Programs (PDMPs) Sufficient to Lead Us out of the Opioid Crisis?

Although the adoption of PDMPs is an effort that holds promise, their ability to stem opioid overprescribing is inherently limited by the specific form of misuse that the programs aim to address. Read more in this insightful Brookings Op-Ed here.